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Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.
Fong, Jia Yi; Pignata, Luca; Goy, Pierre-Alexis; Kawabata, Kimihito Cojin; Lee, Stanley Chun-Wei; Koh, Cheryl M; Musiani, Daniele; Massignani, Enrico; Kotini, Andriana G; Penson, Alex; Wun, Cheng Mun; Shen, Yudao; Schwarz, Megan; Low, Diana Hp; Rialdi, Alexander; Ki, Michelle; Wollmann, Heike; Mzoughi, Slim; Gay, Florence; Thompson, Christine; Hart, Timothy; Barbash, Olena; Luciani, Genna M; Szewczyk, Magdalena M; Wouters, Bas J; Delwel, Ruud; Papapetrou, Eirini P; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H; Minden, Mark D; Jin, Jian; Melnick, Ari; Bonaldi, Tiziana; Abdel-Wahab, Omar; Guccione, Ernesto.
Afiliação
  • Fong JY; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119077, Singapore.
  • Pignata L; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
  • Goy PA; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
  • Kawabata KC; Departments of Medicine and Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA.
  • Lee SC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Koh CM; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore.
  • Musiani D; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20146 Milan, Italy.
  • Massignani E; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20146 Milan, Italy.
  • Kotini AG; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Penson A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Wun CM; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore.
  • Shen Y; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Schwarz M; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Low DH; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore.
  • Rialdi A; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Ki M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Wollmann H; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore.
  • Mzoughi S; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore.
  • Gay F; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore.
  • Thompson C; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Hart T; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Barbash O; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.
  • Luciani GM; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Szewczyk MM; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Wouters BJ; Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA; Department of Hematology, Erasmus University Medical Center, 3015 GD Rotterdam, Netherlands.
  • Delwel R; Department of Hematology, Erasmus University Medical Center, 3015 GD Rotterdam, Netherlands.
  • Papapetrou EP; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Cancer Institute/Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada.
  • Minden MD; Ontario Cancer Institute/Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada.
  • Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Melnick A; Departments of Medicine and Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA.
  • Bonaldi T; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20146 Milan, Italy.
  • Abdel-Wahab O; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: abdelwao@mskcc.org.
  • Guccione E; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Department of Oncological Sciences and Tisch
Cancer Cell ; 36(2): 194-209.e9, 2019 08 12.
Article em En | MEDLINE | ID: mdl-31408619
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Pirróis / RNA Neoplásico / Leucemia Mieloide Aguda / Splicing de RNA / Inibidores Enzimáticos / Etilenodiaminas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Pirróis / RNA Neoplásico / Leucemia Mieloide Aguda / Splicing de RNA / Inibidores Enzimáticos / Etilenodiaminas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos