Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives.
BMC Chem
; 13(1): 102, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31410413
ABSTRACT
We have synthesized new series of bisindole analogs (1-27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 µM respectively when compared with standard pentamidine with IC50 value of 7.20 ± 0.20 µM. All analogs showed greater potential than standard except 10, 19 and 23 when compared with standard. Structure activity relationship has been also established for all compounds. Molecular docking studies were carried out to understand the binding interaction of active molecules.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
BMC Chem
Ano de publicação:
2019
Tipo de documento:
Article
País de publicação:
CH
/
SUIZA
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SUÍÇA
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SWITZERLAND