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Molecular Subtype Classification in Lower-Grade Glioma with Accelerated DTI.
Aliotta, E; Nourzadeh, H; Batchala, P P; Schiff, D; Lopes, M B; Druzgal, J T; Mukherjee, S; Patel, S H.
Afiliação
  • Aliotta E; From the Departments of Radiation Oncology (E.A., H.N.) eric.aliotta@virginia.edu.
  • Nourzadeh H; From the Departments of Radiation Oncology (E.A., H.N.).
  • Batchala PP; Radiology (P.P.B., J.T.D., S.M., S.H.P.).
  • Schiff D; Neurology (D.S.).
  • Lopes MB; Pathology (Neuropathology) (M.B.L.), University of Virginia, Charlottesville, Virginia.
  • Druzgal JT; Radiology (P.P.B., J.T.D., S.M., S.H.P.).
  • Mukherjee S; Radiology (P.P.B., J.T.D., S.M., S.H.P.).
  • Patel SH; Radiology (P.P.B., J.T.D., S.M., S.H.P.).
AJNR Am J Neuroradiol ; 40(9): 1458-1463, 2019 09.
Article em En | MEDLINE | ID: mdl-31413006
ABSTRACT
BACKGROUND AND

PURPOSE:

Image-based classification of lower-grade glioma molecular subtypes has substantial prognostic value. Diffusion tensor imaging has shown promise in lower-grade glioma subtyping but currently requires lengthy, nonstandard acquisitions. Our goal was to investigate lower-grade glioma classification using a machine learning technique that estimates fractional anisotropy from accelerated diffusion MR imaging scans containing only 3 diffusion-encoding directions. MATERIALS AND

METHODS:

Patients with lower-grade gliomas (n = 41) (World Health Organization grades II and III) with known isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status were imaged preoperatively with DTI. Whole-tumor volumes were autodelineated using conventional anatomic MR imaging sequences. In addition to conventional ADC and fractional anisotropy reconstructions, fractional anisotropy estimates were computed from 3-direction DTI subsets using DiffNet, a neural network that directly computes fractional anisotropy from raw DTI data. Differences in whole-tumor ADC, fractional anisotropy, and estimated fractional anisotropy were assessed between IDH-wild-type and IDH-mutant lower-grade gliomas with and without 1p/19q codeletion. Multivariate classification models were developed using whole-tumor histogram and texture features from ADC, ADC + fractional anisotropy, and ADC + estimated fractional anisotropy to identify the added value provided by fractional anisotropy and estimated fractional anisotropy.

RESULTS:

ADC (P = .008), fractional anisotropy (P < .001), and estimated fractional anisotropy (P < .001) significantly differed between IDH-wild-type and IDH-mutant lower-grade gliomas. ADC (P < .001) significantly differed between IDH-mutant gliomas with and without codeletion. ADC-only multivariate classification predicted IDH mutation status with an area under the curve of 0.81 and codeletion status with an area under the curve of 0.83. Performance improved to area under the curve = 0.90/0.94 for the ADC + fractional anisotropy classification and to area under the curve = 0.89/0.89 for the ADC + estimated fractional anisotropy classification.

CONCLUSIONS:

Fractional anisotropy estimates made from accelerated 3-direction DTI scans add value in classifying lower-grade glioma molecular status.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Imagem de Tensor de Difusão / Imagem Molecular / Glioma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: AJNR Am J Neuroradiol Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Imagem de Tensor de Difusão / Imagem Molecular / Glioma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: AJNR Am J Neuroradiol Ano de publicação: 2019 Tipo de documento: Article
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