Correlation of the quantitative level of MGMT promoter methylation and overall survival in primary diagnosed glioblastomas using the quantitative MethyQESD method.

von Rosenstiel, Charlotte; Wiestler, Benedikt; Haller, Bernhard; Schmidt-Graf, Friederike; Gempt, Jens; Bettstetter, Marcus; Rihani, Laura; Wu, Wei; Meyer, Bernhard; Schlegel, Jürgen; Liesche-Starnecker, Friederike

von Rosenstiel, Charlotte; Wiestler, Benedikt; Haller, Bernhard; Schmidt-Graf, Friederike; Gempt, Jens; Bettstetter, Marcus; Rihani, Laura; Wu, Wei; Meyer, Bernhard; Schlegel, Jürgen; Liesche-Starnecker, Friederike.

Afiliação

von Rosenstiel C; Department of Neuropathology, Institute of Pathology, Technical University Munich, School of Medicine, Munich, Germany.
Wiestler B; Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University Munich, School of Medicine, Munich, Germany.
Haller B; Institute of Medical Informatics, Technical University Munich, School of Medicine, Munich, Germany.
Schmidt-Graf F; Department of Neurology, Klinikum rechts der Isar, Technical University Munich, School of Medicine, Munich, Germany.
Gempt J; Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, School of Medicine, Munich, Germany.
Bettstetter M; Teilgemeinschaftspraxis Molekularpathologie Südbayern, Munich, Germany.
Rihani L; Department of Neuropathology, Institute of Pathology, Technical University Munich, School of Medicine, Munich, Germany.
Wu W; Department of Neuropathology, Institute of Pathology, Technical University Munich, School of Medicine, Munich, Germany.
Meyer B; Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, School of Medicine, Munich, Germany.
Schlegel J; Department of Neuropathology, Institute of Pathology, Technical University Munich, School of Medicine, Munich, Germany.
Liesche-Starnecker F; Department of Neuropathology, Institute of Pathology, Technical University Munich, School of Medicine, Munich, Germany friederike.liesche@tum.de.

J Clin Pathol ; 73(2): 112-115, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31422371

Assuntos

Biomarcadores Tumorais/genética; Neoplasias Encefálicas/genética; Metilação de DNA; Metilases de Modificação do DNA/genética; Enzimas Reparadoras do DNA/genética; Glioblastoma/genética; Regiões Promotoras Genéticas; Proteínas Supressoras de Tumor/genética; Adulto; Idoso; Antineoplásicos Alquilantes/uso terapêutico; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/enzimologia; Neoplasias Encefálicas/mortalidade; Feminino; Glioblastoma/tratamento farmacológico; Glioblastoma/enzimologia; Glioblastoma/mortalidade; Humanos; Masculino; Pessoa de Meia-Idade; Prognóstico; Estudos Retrospectivos; Fatores de Risco; Temozolomida/uso terapêutico; Fatores de Tempo

Palavras-chave

MGMT; MethyQESD; brain tumour; glioblastoma; glioma; molecular pathology; overall survival; predictive marker; promoter methylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Metilases de Modificação do DNA / Biomarcadores Tumorais / Regiões Promotoras Genéticas / Glioblastoma / Metilação de DNA / Proteínas Supressoras de Tumor / Enzimas Reparadoras do DNA Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Pathol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido

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