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An oral 2-hydroxypropyl-ß-cyclodextrin-loaded spirooxindole-pyrrolizidine derivative restores p53 activity via targeting MDM2 and JNK1/2 in hepatocellular carcinoma.
Gao, Xiaoge; Wei, Mengxue; Shan, Wenhua; Liu, Qian; Gao, Jian; Liu, Yong; Zhu, Songlei; Yao, Hong.
Afiliação
  • Gao X; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China.
  • Wei M; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China.
  • Shan W; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China.
  • Liu Q; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China.
  • Gao J; Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China.
  • Liu Y; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China.
  • Zhu S; Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China. Electronic address: songleizhu@xzhmu.edu.cn.
  • Yao H; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, PR China; Department of Cancer Biotherapy Center, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650118, PR China. Electronic address: yaohong20055@hotmail.com.
Pharmacol Res ; 148: 104400, 2019 10.
Article em En | MEDLINE | ID: mdl-31425749
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Carcinoma Hepatocelular / Proteína Quinase 8 Ativada por Mitógeno / Proteína Quinase 9 Ativada por Mitógeno / Proteínas Proto-Oncogênicas c-mdm2 / 2-Hidroxipropil-beta-Ciclodextrina / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Holanda
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Carcinoma Hepatocelular / Proteína Quinase 8 Ativada por Mitógeno / Proteína Quinase 9 Ativada por Mitógeno / Proteínas Proto-Oncogênicas c-mdm2 / 2-Hidroxipropil-beta-Ciclodextrina / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Holanda