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Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation.
Xue, Yu; He, Xiaomeng; Yang, Taoyi; Wang, Yuxi; Liu, Zhenming; Zhang, Guisen; Wang, Yanxing; Wang, Kewei; Zhang, Liangren; Zhang, Lihe.
Afiliação
  • Xue Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: bayerxy@163.com.
  • He X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: xhe@bjmu.edu.cn.
  • Yang T; Department of Molecular and Cellular Pharmacology, PKU-IDG/McGovern Institute for Brain Research, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
  • Wang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
  • Liu Z; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
  • Zhang G; Jiangsu Nhwa Pharmaceutical Co. Ltd, 69 Minzhu South Road, Xuzhou, Jiangsu, 221116, PR China.
  • Wang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
  • Wang K; Department of Molecular and Cellular Pharmacology, PKU-IDG/McGovern Institute for Brain Research, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: wangkw@bjmu.edu.cn.
  • Zhang L; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: liangren@bjmu.edu.cn.
  • Zhang L; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: zdszlh@bjmu.edu.cn.
Eur J Med Chem ; 182: 111618, 2019 Nov 15.
Article em En | MEDLINE | ID: mdl-31434041
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Receptor Nicotínico de Acetilcolina alfa7 / Compostos Heterocíclicos / Indolizinas Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: França
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Receptor Nicotínico de Acetilcolina alfa7 / Compostos Heterocíclicos / Indolizinas Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: França