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Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.
Morioka, Kazuhito; Marmor, Yotvat; Sacramento, Jeffrey A; Lin, Amity; Shao, Tiffany; Miclau, Katherine R; Clark, Daniel R; Beattie, Michael S; Marcucio, Ralph S; Miclau, Theodore; Ferguson, Adam R; Bresnahan, Jacqueline C; Bahney, Chelsea S.
Afiliação
  • Morioka K; Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
  • Marmor Y; Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
  • Sacramento JA; Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
  • Lin A; Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
  • Shao T; Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
  • Miclau KR; Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
  • Clark DR; Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
  • Beattie MS; Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
  • Marcucio RS; Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
  • Miclau T; Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
  • Ferguson AR; Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 2550 23rd Street, Building 9, 3rd Floor, San Francisco, CA, 94110, USA.
  • Bresnahan JC; Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF) & Zuckerberg San Francisco General Hospital (ZSFG), 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA, 94110, USA.
  • Bahney CS; San Francisco Veterans Affairs Medical Center, 4150 Clement Street, Building 13, Room 114M, San Francisco, CA, 94121, USA.
Sci Rep ; 9(1): 12199, 2019 08 21.
Article em En | MEDLINE | ID: mdl-31434912
Polytraumatic injuries, specifically long bone fracture and traumatic brain injury (TBI), frequently occur together. Clinical observation has long held that TBI can accelerate fracture healing, yet the complexity and heterogeneity of these injuries has produced conflicting data with limited information on underlying mechanisms. We developed a murine polytrauma model with TBI and fracture to evaluate healing in a controlled system. Fractures were created both contralateral and ipsilateral to the TBI to test whether differential responses of humoral and/or neuronal systems drove altered healing patterns. Our results show increased bone formation after TBI when injuries occur contralateral to each other, rather than ipsilateral, suggesting a role of the nervous system based on the crossed neuroanatomy of motor and sensory systems. Analysis of the humoral system shows that blood cell counts and inflammatory markers are differentially modulated by polytrauma. A data-driven multivariate analysis integrating all outcome measures showed a distinct pathological state of polytrauma and co-variations between fracture, TBI and systemic markers. Taken together, our results suggest that a contralateral bone fracture and TBI alter the local neuroinflammatory state to accelerate early fracture healing. We believe applying a similar data-driven approach to clinical polytrauma may help to better understand the complicated pathophysiological mechanisms of healing.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo Múltiplo / Fraturas Ósseas / Lesões Encefálicas Traumáticas Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo Múltiplo / Fraturas Ósseas / Lesões Encefálicas Traumáticas Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido