Construction of Spirocyclic Tetrahydro-ß-carbolines via Cross-Annulation of Phenols with Tryptamines in Water.
Org Lett
; 21(17): 7033-7037, 2019 09 06.
Article
em En
| MEDLINE
| ID: mdl-31436437
ABSTRACT
Phenols are readily available by degradation of lignin resource. Palladium-catalyzed conversion of phenols to tetrahydro-ß-carboline skeletons bearing a spirocycle at the C-1 position in water is reported. Various substituted phenols are successfully cross-annulated with different tryptamines via sequential C(Ar)-O bond cleavage of phenols, C-H bond activation of tryptamines, and C-N/C-C bond formations. This method provides a new protocol of converting lignin phenols into high-value-added compounds, such as natural product Komavine.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2019
Tipo de documento:
Article