Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters.
Int J Pharm
; 570: 118633, 2019 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-31437563
ABSTRACT
Avobenzone (AVO), oxybenzone (OXY), and octyl methoxycinnamate (OMC), are widely used UV filters. The aim of this study was to investigate the effect of incorporation in mesoporous silica (SBA-15) on their cutaneous deposition and permeation. Stick formulations containing "free" and "incorporated" UV filters (SF1 and SF2, respectively) were prepared and characterized with respect to their physicochemical, thermal, and functional properties. Cutaneous delivery experiments using porcine skin with quantification by UHPLC-MS/MS, demonstrated that skin deposition of AVO and OXY after application of SF2 for 6 and 12â¯h was significantly lower than that from SF1 at each time-point (Student t-test, pâ¯<â¯0.05) e.g. OXY permeation across the skin was 30-, 12- and 1.5-fold lower after 6, 12 and 24â¯h, respectively, following application of SF2. Cutaneous biodistribution profiles of AVO and OXY to 800⯵m evidenced a significant decrease in the amounts in the viable epidermis and dermis. In contrast, deposition of the more lipophilic OMC was not significantly different (pâ¯Ëâ¯0.05). In vitro photoprotective efficacy results demonstrated that adsorption/entrapment of UV filters enhanced the sun protection factor by 94%. In conclusion, SBA-15, an innovative mesoporous material, increased photoprotection by UV filters while reducing their cutaneous penetration and transdermal permeation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Absorção Cutânea
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Raios Ultravioleta
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Dióxido de Silício
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Derme
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Epiderme
Limite:
Animals
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil