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Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.
Tao, Yuyong; Mis, Monika; Blazer, Levi; Ustav, Mart; Steinhart, Zachary; Chidiac, Rony; Kubarakos, Elli; O'Brien, Siobhan; Wang, Xiaomei; Jarvik, Nick; Patel, Nish; Adams, Jarrett; Moffat, Jason; Angers, Stephane; Sidhu, Sachdev S.
Afiliação
  • Tao Y; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Mis M; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
  • Blazer L; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Ustav M; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Steinhart Z; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
  • Chidiac R; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
  • Kubarakos E; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
  • O'Brien S; Department of Biochemistry, University of Toronto, Toronto, Canada.
  • Wang X; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
  • Jarvik N; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Patel N; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Adams J; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Moffat J; Donnelly Centre, University of Toronto, Toronto, Canada.
  • Angers S; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
  • Sidhu SS; Canadian Institute for Advanced Research, Toronto, Canada.
Elife ; 82019 08 27.
Article em En | MEDLINE | ID: mdl-31452509
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Frizzled / Via de Sinalização Wnt / Anticorpos Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Frizzled / Via de Sinalização Wnt / Anticorpos Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá País de publicação: Reino Unido