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CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Kobayashi, Kaoru; Kuze, Jiro; Abe, Satoshi; Takehara, Shoko; Minegishi, Genki; Igarashi, Katsuhide; Kitajima, Satoshi; Kanno, Jun; Yamamoto, Takushi; Oshimura, Mitsuo; Kazuki, Yasuhiro.
Afiliação
  • Kobayashi K; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Kuze J; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Abe S; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Takehara S; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Minegishi G; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Igarashi K; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Kitajima S; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Kanno J; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Yamamoto T; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Oshimura M; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
  • Kazuki Y; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba (K.K., G.M.); Discovery Drug Metabolism & Pharmacokinetics, Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd., Ibaraki (J.Ku.); Chromosome Engineering Research Center (CERC),
Mol Pharmacol ; 96(5): 600-608, 2019 11.
Article em En | MEDLINE | ID: mdl-31455676
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Veia Porta / Citocromo P-450 CYP3A / Indutores do Citocromo P-450 CYP3A / Receptor de Pregnano X / Intestino Delgado / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Veia Porta / Citocromo P-450 CYP3A / Indutores do Citocromo P-450 CYP3A / Receptor de Pregnano X / Intestino Delgado / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos