Hepatoprotective Activity of a Taurine-Rich Water Soluble Extract from Octopus vulgaris Meat.
Adv Exp Med Biol
; 1155: 691-703, 2019.
Article
em En
| MEDLINE
| ID: mdl-31468440
ABSTRACT
In this study, we investigated the hepatoprotective activity of the water extract derived from Octopus vulgaris meat (OM). First of all, a water extract prepared from OM (OMW) showed the high extraction yield (48.22%) and the highest taurine content (39.84%) in free amino acids. OMW exhibited the high value of reducing power, ABTS and hydrogen peroxide radical scavenging activities in dose-dependent manner. The taurine-rich OMW also led to the reduced intracellular reactive oxygen species (ROS) generation with the increased cell survival in H2O2-treated Chang liver cells. In addition, OMW decreased the apoptotic phenomenon, including the formations of apoptotic bodies and sub-G1 DNA contents by regulating the protein expressions of apoptosis-related molecules such as Bcl-2 and Bax. From these results, this study indicated the taurine-rich OMW protected hepatocytes against oxidative stress. These findings suggest that OWM may be a novel potential antioxidant resource.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taurina
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Extratos Celulares
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Estresse Oxidativo
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Hepatócitos
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Octopodiformes
Limite:
Animals
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Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2019
Tipo de documento:
Article