Evaluation of solubility enhancement, antioxidant activity, and cytotoxicity studies of kynurenic acid loaded cyclodextrin nanosponge.
Carbohydr Polym
; 224: 115168, 2019 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-31472867
Kynurenic acid demonstrates antioxidant, neuroprotective and free radical scavenging properties. However, low aqueous solubility of kynurenic acid limits its therapeutic activity. In the present study, cyclodextrin nanosponges were used to improve the solubility and therapeutic activity of kynurenic acid. The formation of kynurenic acid loaded nanosponge was confirmed by different characterization techniques. The solubility of kynurenic acid was significantly increased with nanosponge (111.1⯵g/ml) compared to free kynurenic acid (16.4⯵g/ml) and ß-cyclodextrin (28.6⯵g/ml). High drug loading (19.06%) and encapsulation efficiency (95.31%) were achieved with NS. The particle size and zeta potential of kynurenic acid loaded nanosponge was around 255.8â¯nm and -23â¯mV respectively. Moreover, higher solubilization of kynurenic acid loaded nanosponge produced better antioxidant activity compared to free kynurenic acid. The kynurenic acid loaded nanosponge and blank nanosponge were found nontoxic in the cytotoxicity assay. Thus, these studies demonstrated that nanosponges can be used as a carrier for the delivery of kynurenic acid.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Sequestradores de Radicais Livres
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Ciclodextrinas
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Nanoestruturas
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Ácido Cinurênico
Limite:
Humans
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália
País de publicação:
Reino Unido