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Cardiotoxicity of sorafenib is mediated through elevation of ROS level and CaMKII activity and dysregulation of calcium homoeostasis.
Ma, Wenzhuo; Liu, Mei; Liang, Fanfan; Zhao, Lili; Gao, Chenying; Jiang, Xixi; Zhang, Xin; Zhan, Heqin; Hu, Hao; Zhao, Zhenghang.
Afiliação
  • Ma W; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Liu M; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Liang F; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Zhao L; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Gao C; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Jiang X; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Zhang X; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Zhan H; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
  • Hu H; Department of Pharmacology, College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
  • Zhao Z; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Health Science Center, Xi'an, China.
Basic Clin Pharmacol Toxicol ; 126(2): 166-180, 2020 Feb.
Article em En | MEDLINE | ID: mdl-31483925
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Cardiotoxicidade / Sorafenibe / Antineoplásicos Limite: Animals Idioma: En Revista: Basic Clin Pharmacol Toxicol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Cardiotoxicidade / Sorafenibe / Antineoplásicos Limite: Animals Idioma: En Revista: Basic Clin Pharmacol Toxicol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido