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An exploration of solvent-front region high affinity moiety leading to novel potent ALK & ROS1 dual inhibitors with mutant-combating effects.
Lei, Hongrui; Jia, Fang; Cao, Meng; Wang, Jie; Guo, Ming; Zhu, Minglin; Zuo, Daiying; Zhai, Xin.
Afiliação
  • Lei H; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Jia F; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Cao M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang J; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Guo M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Zhu M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Zuo D; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: zuodaiying@163.com.
  • Zhai X; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: zhaixin_syphu@126.com.
Bioorg Med Chem ; 27(20): 115051, 2019 10 15.
Article em En | MEDLINE | ID: mdl-31492532
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Proteínas Proto-Oncogênicas / Inibidores de Proteínas Quinases / Diaminas / Quinase do Linfoma Anaplásico Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Proteínas Tirosina Quinases / Proteínas Proto-Oncogênicas / Inibidores de Proteínas Quinases / Diaminas / Quinase do Linfoma Anaplásico Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido