Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis.

Yang, Dongqin; Zhang, Qi; Ma, Yunfang; Che, Zhihui; Zhang, Wenli; Wu, Mengmeng; Wu, Lijun; Liu, Fuchen; Chu, Yiwei; Xu, Wei; McGrath, Mary; Song, Chunhua; Liu, Jie

Yang, Dongqin; Zhang, Qi; Ma, Yunfang; Che, Zhihui; Zhang, Wenli; Wu, Mengmeng; Wu, Lijun; Liu, Fuchen; Chu, Yiwei; Xu, Wei; McGrath, Mary; Song, Chunhua; Liu, Jie.

Afiliação

Yang D; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China. Electronic address: kobesakura@fudan.edu.cn.
Zhang Q; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China.
Ma Y; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China.
Che Z; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China.
Zhang W; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China.
Wu M; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China.
Wu L; Department of Library, Fudan University, Shanghai, China.
Liu F; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Chu Y; Department of Immunology of School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xu W; Department of Immunology of School of Basic Medical Sciences, Fudan University, Shanghai, China.
McGrath M; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Song C; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Liu J; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China. Electronic address: jieliu@fudan.edu.cn.

EBioMedicine ; 47: 114-127, 2019 Sep.

Article em En | MEDLINE | ID: mdl-31495718

Assuntos

Adenosina/farmacologia; Apoptose/efeitos dos fármacos; Senescência Celular/efeitos dos fármacos; Neoplasias Pancreáticas/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas ras/metabolismo; Animais; Apoptose/genética; Biomarcadores Tumorais; Linhagem Celular Tumoral; Senescência Celular/genética; Modelos Animais de Doenças; Inativação Gênica; Humanos; Imuno-Histoquímica; Camundongos; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patologia; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/genética; Ensaios Antitumorais Modelo de Xenoenxerto; Proteínas ras/genética

Palavras-chave

Adenosine; Akt-p21 axis; GSK690693; Pancreatic cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Adenosina / Senescência Celular / Apoptose / Proteínas ras / Proteínas Proto-Oncogênicas c-akt Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: EBioMedicine Ano de publicação: 2019 Tipo de documento: Article País de publicação: Holanda

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