The Importance of RET-He in the Diagnosis of Iron Deficiency and Iron Deficiency Anemia and the Evaluation of Response to Oral Iron Therapy.
J Med Biochem
; 38(4): 496-502, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31496915
ABSTRACT
BACKGROUND:
The purpose of this study is to investigate whether or not reticulocyte hemoglobin equivalent (RET-He) is a superior indicator of blood count and other iron parameters in terms of diagnosing iron deficiency (ID) and iron deficiency anemia (IDA), and thus evaluating a patient's response to oral iron treatment.METHODS:
The research population consisted of 217 participants in total 54 control, 53 ID, 58 non-ID anemia, and 52 IDA patients. A hemoglobin (Hb) value of < 130.0 g/L was defined as indicating anemia for men, while an Hb value of < 120.0 g/L was defined as indicating anemia for women. All patients were administered 270 mg oral elemental iron sulphate daily.RESULTS:
The RET-He was significantly lower in the IDA group, compared to other groups (IDA 21.0 ± 4.1, ID 26.0 ± 4.9, non-ID anemia 32.1 ± 6.8, control 36.6 ± 7.0; < 0.001). The ID group had a lower RET-He compared to the non-ID anemia group and the control group. On the 5th day of treatment, the ID and IDA group showed no significant differences in terms of Hb while the RET-He level demonstrated a significant increase. The increase in the RET-He level observed in the IDA group on the 5th day was significantly higher compared to the increase observed in the ID group. A RET-He value of 25.4 pg and below predicted ID diagnosis with 90.4% sensitivity and 49.1% specificity in IDA patients, compared to the ID group.CONCLUSIONS:
The results of our study, therefore, suggest that RET-He may be a clinically useful marker in the diagnosis of ID and IDA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
J Med Biochem
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Turquia