Haemostatic changes in urogenital schistosomiasis haematobium: a case-control study in Gabonese schoolchildren.
J Helminthol
; 94: e84, 2019 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-31500673
ABSTRACT
In many tropical areas schistosomiasis is a major health problem causing hepatosplenic, intestinal or urogenital complaints. Hepatosplenic schistosomiasis mansoni is also characterized by blood coagulation abnormalities. Liver pathology plays a role in the development of haemostatic changes and the parasitic infection may directly affect coagulation. However, these contributing factors cannot be studied separately in hepatosplenic schistosomiasis infections. This pilot study provides insight in haemostatic changes in urinary schistosomiasis by studying coagulation parameters in schistosomiasis haematobium-infected Gabonese schoolchildren. Selection on urinary schistosomiasis patients without hepatosplenic complaints allows for the investigation of the direct effects of the parasite on haemostasis. Levels of von Willebrand Factor (VWF) antigen, active VWF and osteoprotegerin were elevated, indicating inflammation-mediated endothelial activation. In contrast to hepatosplenic schistosomiasis, thrombin-antithrombin complex and D-dimer levels were not affected. Despite its small sample size, this study clearly indicates that Schistosoma haematobium directly alters the activation status of the endothelium, without initiation of coagulation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Instituições Acadêmicas
/
Infecções Urinárias
/
Coagulação Sanguínea
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Esquistossomose Urinária
/
Hemostáticos
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Animals
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Child
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Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Helminthol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Holanda
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM