Modulation of the 5-HT3A receptor current by desacylbaldrinal.
Nat Prod Res
; 35(16): 2758-2762, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-31502480
ABSTRACT
The serotonin (5-hydroxytryptamine) type 3 receptor is an important target in the control of digestive dysfunction such as anorexia and bulimia, and 5-HT3 receptor antagonists are effective against eating disorder and the early-phase chemotherapy and radiotherapy evoked vomiting. Our previous research of Valeriana jatamansi revealed the presence of iridoids, which showed potent antitumor activities. Here, we explored the effects of 10π aromatic iridoid desacylbaldrinal isolated from V. jatamansi on the 5-HT3 receptor current. We performed whole cell recordings of 5-HT3A receptor currents in the presence of the compound. The result indicated that desacylbaldrinal inhibited the 5-HT-mediated 5-HT3A receptor current.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Valeriana
/
Serotonina
/
Iridoides
/
Receptores 5-HT3 de Serotonina
/
Antagonistas do Receptor 5-HT3 de Serotonina
Limite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China