Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript.

Zhao, Xiaoxu; Cui, Limei; Xiao, Yun; Mao, Qin; Aishanjiang, Maerhaba; Kong, Wanzhong; Liu, Yuqi; Chen, Hong; Hong, Fang; Jia, Zidong; Wang, Meng; Jiang, Pingping; Guan, Min-Xin

Zhao, Xiaoxu; Cui, Limei; Xiao, Yun; Mao, Qin; Aishanjiang, Maerhaba; Kong, Wanzhong; Liu, Yuqi; Chen, Hong; Hong, Fang; Jia, Zidong; Wang, Meng; Jiang, Pingping; Guan, Min-Xin.

Afiliação

Zhao X; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Cui L; Institute of Genetics, and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Xiao Y; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Mao Q; Institute of Genetics, and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Aishanjiang M; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Kong W; Institute of Genetics, and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Liu Y; Institute of Genetics, and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Chen H; Institute of Genetics, and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Hong F; Department of Clinical Laboratory, Wenzhou Traditional Chinese Medicine Hospital, Wenzhou, Zhejiang 325000, China.
Jia Z; Cardiac Department, Chinese PLA General Hospital, Beijing 100853, China.
Wang M; Emergy Medicine Department, Ningbo First Hospital, Zhejiang University School of Medicine, Ningbo, Zhejiang 315000, China.
Jiang P; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Guan MX; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

Nucleic Acids Res ; 47(19): 10340-10356, 2019 11 04.

Article em En | MEDLINE | ID: mdl-31504769

Assuntos

DNA Mitocondrial/genética; Hipertensão/genética; RNA de Transferência de Metionina/genética; Transcrição Gênica; Células Endoteliais da Veia Umbilical Humana; Humanos; Mutação/genética; NADH Desidrogenase/genética; Processamento Pós-Transcricional do RNA/genética; RNA Ribossômico/genética; RNA Ribossômico 16S/genética; RNA de Transferência de Glutamina/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / DNA Mitocondrial / RNA de Transferência de Metionina / Hipertensão Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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