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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
Vande Walle, Lieselotte; Stowe, Irma B; Sácha, Pavel; Lee, Bettina L; Demon, Dieter; Fossoul, Amelie; Van Hauwermeiren, Filip; Saavedra, Pedro H V; Simon, Petr; Subrt, Vladimír; Kostka, Libor; Stivala, Craig E; Pham, Victoria C; Staben, Steven T; Yamazoe, Sayumi; Konvalinka, Jan; Kayagaki, Nobuhiko; Lamkanfi, Mohamed.
Afiliação
  • Vande Walle L; Inflammation Research Center, VIB, Ghent, Belgium.
  • Stowe IB; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Sácha P; Discovery Sciences, Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium.
  • Lee BL; Department of Physiological Chemistry, Genentech, South San Francisco, California, United States of America.
  • Demon D; Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences, Prague, Czech Republic.
  • Fossoul A; Department of Physiological Chemistry, Genentech, South San Francisco, California, United States of America.
  • Van Hauwermeiren F; Inflammation Research Center, VIB, Ghent, Belgium.
  • Saavedra PHV; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Simon P; Inflammation Research Center, VIB, Ghent, Belgium.
  • Subrt V; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Kostka L; Inflammation Research Center, VIB, Ghent, Belgium.
  • Stivala CE; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Pham VC; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium.
  • Staben ST; Inflammation Research Center, VIB, Ghent, Belgium.
  • Yamazoe S; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Konvalinka J; Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences, Prague, Czech Republic.
  • Kayagaki N; Institute of Macromolecular Chemistry, Academy of Science of the Czech Republic, Prague, Czech Republic.
  • Lamkanfi M; Institute of Macromolecular Chemistry, Academy of Science of the Czech Republic, Prague, Czech Republic.
PLoS Biol ; 17(9): e3000354, 2019 09.
Article em En | MEDLINE | ID: mdl-31525186
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Síndromes Periódicas Associadas à Criopirina / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Furanos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: PLoS Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Síndromes Periódicas Associadas à Criopirina / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Furanos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: PLoS Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica