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Occupational exposure to wood dust and risk of lung cancer: the ICARE study.
Matrat, Mireille; Radoï, Loredana; Févotte, Joëlle; Guida, Florence; Cénée, Sylvie; Cyr, Diane; Sanchez, Marie; Menvielle, Gwenn; Schmaus, Annie; Marrer, Emilie; Luce, Danièle; Stücker, Isabelle.
Afiliação
  • Matrat M; Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, U1018, Equipe Epidemiologie des Cancers, Gènes et Environnement, INSERM, Villejuif, France mireille.matrat@inserm.fr.
  • Radoï L; Faculty of Medicine IFR 10, University Paris-Est Créteil, Créteil, France.
  • Févotte J; Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, U1018, Equipe Epidemiologie des Cancers, Gènes et Environnement, INSERM, Villejuif, France.
  • Guida F; Faculty of Dental Surgery, University Paris Descartes, Paris, France.
  • Cénée S; Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), Université Claude Bernard Lyon 1, Lyon, France.
  • Cyr D; Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, U1018, Equipe Epidemiologie des Cancers, Gènes et Environnement, INSERM, Villejuif, France.
  • Sanchez M; Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, U1018, Equipe Epidemiologie des Cancers, Gènes et Environnement, INSERM, Villejuif, France.
  • Menvielle G; Population-Based Epidemiological Cohorts Unit (UMS 011) INSERM-UVSQ, INSERM, Villejuif, France.
  • Schmaus A; UMS 011, University of Versailles St-Quentin, Villejuif, France.
  • Marrer E; Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, U1018, Equipe Epidemiologie des Cancers, Gènes et Environnement, INSERM, Villejuif, France.
  • Luce D; Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP, UMR1136), Sorbonne Universités, INSERM, Paris, France.
  • Stücker I; Population-Based Epidemiological Cohorts Unit (UMS 011) INSERM-UVSQ, INSERM, Villejuif, France.
Occup Environ Med ; 76(12): 901-907, 2019 12.
Article em En | MEDLINE | ID: mdl-31537717
OBJECTIVES: In a previous analysis of data from a French population-based case-control study (the Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE) study), 'having ever worked' in wood-related occupations was associated with excess lung cancer risk after adjusting for smoking but not for occupational factors. The present study aimed to investigate the relationship between lung cancer risk and wood dust exposure after adjusting for occupational exposures. METHODS: Data were obtained from 2276 cases and 2780 controls on smoking habits and lifelong occupational history, using a standardised questionnaire with a job-specific questionnaire for wood dust exposure. Logistic regression models were used to calculate ORs and 95% CIs adjusted for age, area of residence, tobacco smoking, the number of job periods and exposure to silica, asbestos and diesel motor exhaust (DME). RESULTS: No significant association was found between lung cancer and wood dust exposure after adjustment for smoking, asbestos, silica and DME exposures. The risk of lung cancer was slightly increased among those who were exposed to wood dust more than 10 years, and had over 40 years since the first exposure. CONCLUSION: Our findings do not provide a strong support to the hypothesis that wood dust exposure is a risk factor for lung cancer. This study showed the importance of taking into account smoking and occupational coexposures in studies on lung cancer and wood dust exposure. Further studies evaluating the level and frequency of exposure during various tasks in woodwork are needed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Madeira / Exposição Ocupacional / Exposição por Inalação / Poeira / Neoplasias Pulmonares / Doenças Profissionais Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Occup Environ Med Assunto da revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Madeira / Exposição Ocupacional / Exposição por Inalação / Poeira / Neoplasias Pulmonares / Doenças Profissionais Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Occup Environ Med Assunto da revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido