Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study.
Invest Ophthalmol Vis Sci
; 60(12): 3930-3936, 2019 09 03.
Article
em En
| MEDLINE
| ID: mdl-31546258
ABSTRACT
Purpose:
We describe changes in choroidal thickness from age 11 to 16 years and its association with ocular biometrics and body development.Method:
In this longitudinal, population-based observational study, choroidal thickness was measured subfoveally and 1- and 3-mm temporal thereof using enhanced depth imaging spectral domain optical coherence tomography. Analyses were stratified by sex and adjusted for age and the time of day that the scan was performed.Results:
The study included 687 participants (304 boys). Median (interquartile range [IQR]) age was 11.5 (0.6) years at baseline and 16.6 (0.3) years at follow-up. Mean increase in choroidal thickness was 33, 27, and 11 µm at the three respective locations. The subfoveal choroid thickened less in eyes whose axial length increased more (boys, ß = -85 µm/mm; 95% confidence interval [CI], -104 to -66, P < 0.0001; girls, ß = -105 µm/mm; 95% CI, -121 to -89, P < 0.0001) and in eyes with a more negative refractive development (boys, 11 µm/diopters [D]; 95% CI, 4.0 to 18, P = 0.0022; girls, 22 µm/D; 95% CI, 16 to 27, P < 0.0001). Subfoveal choroidal thickness increased less in girls who underwent early puberty (Tanner stage 4 vs. 1; -39 µm' 95% CI, -72 to -5.9, P = 0.021) and who had a longer baseline axial length (ß = -8.6 µm/mm; 95% CI, -15 to -2.7, P = 0.0043), and more in girls who grew taller (ß = 0.9 µm/cm; 95% CI, 0.1 to 1.7, P = 0.026).Conclusions:
The choroid increased in thickness from age 11 to 16 years. The increase was greater in girls with later sexual maturation and smaller in eyes that added more axial length and had a relatively negative refractive development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Constituição Corporal
/
Corioide
/
Comprimento Axial do Olho
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Dinamarca