Controlling the AP Controller: Controller Performance Assessment and Modification.
J Diabetes Sci Technol
; 13(6): 1091-1104, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31561714
ABSTRACT
BACKGROUND:
Despite recent advances in closed-loop control of blood glucose concentration (BGC) in people with type 1 diabetes (T1D), online performance assessment and modification of artificial pancreas (AP) control systems remain a challenge as the metabolic characteristics of users change over time.METHODS:
A controller performance assessment and modification system (CPAMS) analyzes the glucose concentration variations and controller behavior, and modifies the parameters of the control system used in the multivariable AP system. Various indices are defined to quantitatively evaluate the controller performance in real time. Controller performance assessment and modification system also incorporates online learning from historical data to anticipate impending disturbances and proactively counteract their effects.RESULTS:
Using a multivariable simulation platform for T1D, the CPAMS is used to enhance the BGC regulation in people with T1D by means of automated insulin delivery with an adaptive learning predictive controller. Controller performance assessment and modification system increases the percentage of time in the target range (70-180) mg/dL by 52.3% without causing any hypoglycemia and hyperglycemia events.CONCLUSIONS:
The results demonstrate a significant improvement in the multivariable AP controller performance by using CPAMS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Pâncreas Artificial
/
Diabetes Mellitus Tipo 1
/
Hipoglicemiantes
/
Insulina
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Diabetes Sci Technol
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos