Your browser doesn't support javascript.
loading
Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green.
Mokrousov, Maksim D; Novoselova, Marina V; Nolan, Jackie; Harrington, Walter; Rudakovskaya, Polina; Bratashov, Daniil N; Galanzha, Ekaterina I; Fuenzalida-Werner, Juan Pablo; Yakimov, Boris P; Nazarikov, Gleb; Drachev, Vladimir P; Shirshin, Evgeny A; Ntziachristos, Vasilis; Stiel, Andre C; Zharov, Vladimir P; Gorin, Dmitry A.
Afiliação
  • Mokrousov MD; Skolkovo Institute of Science and Technology, 3 Nobelya Str, Moscow, 121205, Russia.
  • Novoselova MV; Skolkovo Institute of Science and Technology, 3 Nobelya Str, Moscow, 121205, Russia.
  • Nolan J; University of Arkansas for Medical Sciences, 4301 W. Markham St. Little Rock, AR 72205, USA.
  • Harrington W; University of Arkansas for Medical Sciences, 4301 W. Markham St. Little Rock, AR 72205, USA.
  • Rudakovskaya P; Skolkovo Institute of Science and Technology, 3 Nobelya Str, Moscow, 121205, Russia.
  • Bratashov DN; Saratov State University, 83 Astrakhanskaya Str, Saratov, 410012, Russia.
  • Galanzha EI; University of Arkansas for Medical Sciences, 4301 W. Markham St. Little Rock, AR 72205, USA.
  • Fuenzalida-Werner JP; Saratov State University, 83 Astrakhanskaya Str, Saratov, 410012, Russia.
  • Yakimov BP; Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany.
  • Nazarikov G; Lomonosov Moscow State University, Leninskie gory 1/2, 119991, Moscow, Russia.
  • Drachev VP; Skolkovo Institute of Science and Technology, 3 Nobelya Str, Moscow, 121205, Russia.
  • Shirshin EA; Skolkovo Institute of Science and Technology, 3 Nobelya Str, Moscow, 121205, Russia.
  • Ntziachristos V; University of North Texas, 1155 Union Circle, Denton, TX 76203, USA.
  • Stiel AC; Lomonosov Moscow State University, Leninskie gory 1/2, 119991, Moscow, Russia.
  • Zharov VP; Institute of Spectroscopy of the Russian Academy of Sciences, Fizicheskaya Str., 5, 108840, Troitsk, Moscow, Russia.
  • Gorin DA; Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg, Germany.
Biomed Opt Express ; 10(9): 4775-4789, 2019 Sep 01.
Article em En | MEDLINE | ID: mdl-31565524
ABSTRACT
A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety.
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Opt Express Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Federação Russa