HMGB1-C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis.

Liu, Tianye; Xiang, Alec; Peng, Travis; Doran, Amanda C; Tracey, Kevin J; Barnes, Betsy J; Tabas, Ira; Son, Myoungsun; Diamond, Betty

Liu, Tianye; Xiang, Alec; Peng, Travis; Doran, Amanda C; Tracey, Kevin J; Barnes, Betsy J; Tabas, Ira; Son, Myoungsun; Diamond, Betty.

Afiliação

Liu T; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Xiang A; MD/PhD Program at Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549.
Peng T; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Doran AC; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Tracey KJ; Department of Medicine, Columbia University, New York, NY 10032.
Barnes BJ; Department of Physiology, Columbia University, New York, NY 10032.
Tabas I; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032.
Son M; The Center for Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Diamond B; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030.

Proc Natl Acad Sci U S A ; 116(46): 23254-23263, 2019 11 12.

Article em En | MEDLINE | ID: mdl-31570601

Assuntos

Complemento C1q/metabolismo; Proteína HMGB1/metabolismo; Macrófagos/fisiologia; Animais; Araquidonato 5-Lipoxigenase/metabolismo; Fatores Reguladores de Interferon/metabolismo; Leucotrieno B4/biossíntese; Camundongos Endogâmicos C57BL; Monócitos/metabolismo; Peritonite/induzido quimicamente; Peritonite/imunologia; Receptor para Produtos Finais de Glicação Avançada/metabolismo; Receptores Imunológicos/metabolismo

Palavras-chave

C1q; HMGB1; IRF5; SPMs; leukotriene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complemento C1q / Proteína HMGB1 / Macrófagos Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

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