Effects of mono- and dialkylglucosides on the characterisation and blood circulation of lipid nanoemulsions.
J Microencapsul
; 36(8): 738-746, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31573357
ABSTRACT
Aim:
Effects of two cosurfactants, n-alkylglycosides with mono- or disaccharide groups - N-nonyl ß-D-glucopyranoside (N-Glu) and N-decyl ß-D-maltoside (D-Mal) - were studied to the stability in saline solution, interaction with serum albumin, and blood circulation of the lipid nanoemulsion (LNE).Methods:
The LNEs composed of soybean oil, phosphatidylcholine, and sodium palmitate were prepared without (Control-LNE) and with N-Glu or D-Mal (NG-LNE and DM-LNE, respectively).Results:
In saline solution, NG-LNE exhibited a smaller droplet size than Control-LNE, while the size of DM-LNE was significantly increased compared with the other LNEs. The fluorescence resonance energy transfer method showed that the order of albumin interaction was DM-LNE > NG-LNE > Control-LNE. In vivo blood circulation in mice, showed greater fractions of both NG-LNE and DM-LNE remaining in blood over time compared with Control-LNE.Conclusions:
The nature of high stability in saline solution and high affinity for serum albumin led to the prolonged circulation of LNE.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tensoativos
/
Emulsões
/
Nanopartículas
/
Glucosídeos
/
Lipídeos
Limite:
Animals
Idioma:
En
Revista:
J Microencapsul
Assunto da revista:
FARMACIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão