Interfacing the neural output of the spinal cord: robust and reliable longitudinal identification of motor neurons in humans.
J Neural Eng
; 17(1): 016003, 2019 12 05.
Article
em En
| MEDLINE
| ID: mdl-31604338
ABSTRACT
OBJECTIVE:
Non-invasive electromyographic techniques can detect action potentials from muscle units with high spatial dimensionality. These technologies allow the decoding of large samples of motor units by using high-density grids of electrodes that are placed on the skin overlying contracting muscles and therefore provide a non-invasive representation of the human spinal cord output.APPROACH:
From a sample of >1200 decoded motor neurons, we show that motor neuron activity can be identified in humans in the full muscle recruitment range with high accuracy. MAINRESULTS:
After showing the validity of decomposition with novel test parameters, we demonstrate that the same motor neurons can be tracked over a period of one-month, which allows for the longitudinal analysis of individual human neural cells.SIGNIFICANCE:
These results show the potential of an accurate and reliable assessment of large populations of motor neurons in physiological investigations. We discuss the potential of this non-invasive neural interfacing technology for the study of the neural determinants of movement and man-machine interfacing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Músculo Esquelético
/
Eletromiografia
/
Neurônios Motores
/
Contração Muscular
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Neural Eng
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Reino Unido