Spironolactone suppresses aldosterone-induced Kv1.5 expression by attenuating mineralocorticoid receptor-Nox1/2/4-mediated ROS generation in neonatal rat atrial myocytes.

Lu, Guihua; Li, Jie; Zhai, Yuansheng; Li, Qinglang; Xie, Dongmei; Zhang, Juhong; Xiao, Ying; Gao, Xiuren

Lu, Guihua; Li, Jie; Zhai, Yuansheng; Li, Qinglang; Xie, Dongmei; Zhang, Juhong; Xiao, Ying; Gao, Xiuren.

Afiliação

Lu G; Department of Cardiology, Heart Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, China.
Li J; Department of Cardiology, Heart Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, China.
Zhai Y; Department of Cardiology, Heart Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, China.
Li Q; Department of Cardiology, Heart Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, China.
Xie D; Department of Cardiology, Heart Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, China.
Zhang J; Department of Cardiology, Heart Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, China.
Xiao Y; Department of Anesthesiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address: xying2603@163.com.
Gao X; Department of Cardiology, Heart Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address: xiurengao@foxmail.com.

Biochem Biophys Res Commun ; 520(2): 379-384, 2019 12 03.

Article em En | MEDLINE | ID: mdl-31606204

Assuntos

Canal de Potássio Kv1.5/metabolismo; Miócitos Cardíacos/efeitos dos fármacos; Miócitos Cardíacos/metabolismo; Receptores de Mineralocorticoides/metabolismo; Espironolactona/farmacologia; Aldosterona/farmacologia; Angiotensina II/metabolismo; Angiotensina II/farmacologia; Animais; Animais Recém-Nascidos; Átrios do Coração/citologia; NADPH Oxidase 1/metabolismo; NADPH Oxidase 2/metabolismo; NADPH Oxidase 4/antagonistas & inibidores; NADPH Oxidase 4/metabolismo; Pirazóis/farmacologia; Pirazolonas; Piridinas/farmacologia; Piridonas; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Aldosterone; Atrial fibrillation; Kv1.5; Mineralocorticoid receptor; NADPH oxidase; Reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espironolactona / Receptores de Mineralocorticoides / Miócitos Cardíacos / Canal de Potássio Kv1.5 Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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