Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt<sup>Q140/Q140</sup> mouse model of Huntington's disease.

McAdam, Robyn L; Morton, Andrew; Gordon, Sarah L; Alterman, Julia F; Khvorova, Anastasia; Cousin, Michael A; Smillie, Karen J

Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt^Q140/Q140 mouse model of Huntington's disease.

McAdam, Robyn L; Morton, Andrew; Gordon, Sarah L; Alterman, Julia F; Khvorova, Anastasia; Cousin, Michael A; Smillie, Karen J.

Afiliação

McAdam RL; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK.
Morton A; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK.
Gordon SL; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK.
Alterman JF; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Khvorova A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Cousin MA; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK. Electronic address: M.Cousin@ed.ac.uk.
Smillie KJ; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK. Electronic address: K.Smillie@ed.ac.uk.

Neurobiol Dis ; 134: 104637, 2020 02.

Article em En | MEDLINE | ID: mdl-31614197

Assuntos

Corpo Estriado/metabolismo; Endocitose/fisiologia; Proteína Huntingtina/metabolismo; Doença de Huntington/metabolismo; Neurônios/metabolismo; Vesículas Sinápticas/metabolismo; Animais; Modelos Animais de Doenças; Técnicas de Introdução de Genes; Humanos; Proteína Huntingtina/genética; Doença de Huntington/genética; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

Clathrin; Endocytosis; Endosome; Huntington's disease; Neurodegeneration; Neuron; Synapse; Vesicle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Sinápticas / Doença de Huntington / Corpo Estriado / Endocitose / Proteína Huntingtina / Neurônios Limite: Animals / Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos

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