Modulating intramolecular chalcogen bonds in aromatic (thio)(seleno)phene-based derivatives.
Phys Chem Chem Phys
; 21(42): 23645-23650, 2019 Nov 14.
Article
em En
| MEDLINE
| ID: mdl-31625544
ABSTRACT
Intramolecular interactions have been proven to be the key to conformational control in drug-design. While chalcogen interactions have been shown to be present in certain ligands of the GK-GKRP target protein, in the present study, intramolecular chalcogen interactions through selenium are found to be even more promising since they form stronger interactions. Also, the flexibility/rigidity of the carbon backbone of the corresponding ligands is crucial in the conformational stability.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Phys Chem Chem Phys
Assunto da revista:
BIOFISICA
/
QUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Irlanda