Overview of biological mechanisms of human carcinogens.
J Toxicol Environ Health B Crit Rev
; 22(7-8): 288-359, 2019.
Article
em En
| MEDLINE
| ID: mdl-31631808
ABSTRACT
This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Carcinogênese
/
Neoplasias
Tipo de estudo:
Overview
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Toxicol Environ Health B Crit Rev
Assunto da revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá