Inactivation of TFEB and NF-<i>&#954;</i>B by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion.

Niu, Huanmin; Qian, Lilin; Sun, Bin; Liu, Wenjian; Wang, Fang; Wang, Qian; Ji, Xiaotian; Luo, Yanhai; Nesa, Effat Un; Lou, Hongxiang; Yuan, Huiqing

Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion.

Niu, Huanmin; Qian, Lilin; Sun, Bin; Liu, Wenjian; Wang, Fang; Wang, Qian; Ji, Xiaotian; Luo, Yanhai; Nesa, Effat Un; Lou, Hongxiang; Yuan, Huiqing.

Afiliação

Niu H; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.
Qian L; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.
Sun B; Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Liu W; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.
Wang F; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.
Wang Q; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.
Ji X; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.
Luo Y; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.
Nesa EU; Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China.
Lou H; Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Yuan H; Institute of Medical Sciences/Department of Biochemistry and Molecular Biology, the Second Hospital of Shandong University, Jinan 250033, China.

Acta Pharm Sin B ; 9(5): 923-936, 2019 Sep.

Article em En | MEDLINE | ID: mdl-31649843

Palavras-chave

ALT, glutamic-pyruvic transaminase; AST, transaminase; BUN, blood urea nitrogen; CDDP, cisplatin; CI, combinatory index; CM, conditioned media; CREA, creatinine; CT-like, both chymotrypsin-like; DMSO, dimethyl sulfoxide; Doc, docetaxel; Doxo, doxorubicin; Drug resistance; EdU, 5-ethynyl-2'-deoxyuridine; LPS, lipopolysaccharide; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Mar-M, Marchantin M; Marchantin M; NF-κB; NF-κB, nuclear factor-κB; PGPH, peptidylglutamyl hydrolyzing; PI, propidium iodide; ROS, reactive oxygen species; SA-ß-gal, senescence-associated ß-galactosidase; SASP; SASP, senescence-associated secretory phenotype; Sv, starvation; TCGA, the Cancer Genome Atlas; TFEB; TFEB, transcription factor EB; Tg, thapsigargin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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