The Low-Dimensional Neural Architecture of Cognitive Complexity Is Related to Activity in Medial Thalamic Nuclei.
Neuron
; 104(5): 849-855.e3, 2019 12 04.
Article
em En
| MEDLINE
| ID: mdl-31653463
ABSTRACT
Cognitive activity emerges from large-scale neuronal dynamics that are constrained to a low-dimensional manifold. How this low-dimensional manifold scales with cognitive complexity, and which brain regions regulate this process, are not well understood. We addressed this issue by analyzing sub-second high-field fMRI data acquired during performance of a task that systematically varied the complexity of cognitive reasoning. We show that task performance reconfigures the low-dimensional manifold and that deviations from these patterns relate to performance errors. We further demonstrate that individual differences in thalamic activity relate to reconfigurations of the low-dimensional architecture during task engagement.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Núcleo Mediodorsal do Tálamo
Limite:
Adolescent
/
Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article