Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.
Nat Metab
; 1(5): 532-545, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-31656947
ABSTRACT
Elevated branched chain amino acids (BCAAs) are associated with obesity and insulin resistance. How long-term dietary BCAAs impact late-life health and lifespan is unknown. Here, we show that when dietary BCAAs are varied against a fixed, isocaloric macronutrient background, long-term exposure to high BCAA diets leads to hyperphagia, obesity and reduced lifespan. These effects are not due to elevated BCAA per se or hepatic mTOR activation, but rather due to a shift in the relative quantity of dietary BCAAs and other AAs, notably tryptophan and threonine. Increasing the ratio of BCAAs to these AAs resulted in hyperphagia and is associated with central serotonin depletion. Preventing hyperphagia by calorie restriction or pair-feeding averts the health costs of a high BCAA diet. Our data highlight a role for amino acid quality in energy balance and show that health costs of chronic high BCAA intakes need not be due to intrinsic toxicity but, rather, a consequence of hyperphagia driven by AA imbalance.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação do Apetite
/
Expectativa de Vida
/
Aminoácidos
/
Aminoácidos de Cadeia Ramificada
Aspecto:
Patient_preference
Limite:
Animals
Idioma:
En
Revista:
Nat Metab
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália