Identification of quinoxalin-2(1<i>H</i>)-one derivatives as a novel class of multifunctional aldose reductase inhibitors.

Hao, Xin; Qin, Xiangyu; Zhang, Xin; Ma, Bing; Qi, Gang; Yu, Taiming; Han, Zhongfei; Zhu, Changjin

Identification of quinoxalin-2(1H)-one derivatives as a novel class of multifunctional aldose reductase inhibitors.

Hao, Xin; Qin, Xiangyu; Zhang, Xin; Ma, Bing; Qi, Gang; Yu, Taiming; Han, Zhongfei; Zhu, Changjin.

Afiliação

Hao X; Faculty of Chemistry and Chemical Engineering, Yancheng Institute of Technology, No. 1 Xiwangdadao Street, 221051 Yancheng, PR China.
Qin X; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, No. 5, Zhongguancun South Street, 100081 Beijing, PR China.
Zhang X; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, No. 5, Zhongguancun South Street, 100081 Beijing, PR China.
Ma B; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, No. 5, Zhongguancun South Street, 100081 Beijing, PR China.
Qi G; Faculty of Chemistry and Chemical Engineering, Yancheng Institute of Technology, No. 1 Xiwangdadao Street, 221051 Yancheng, PR China.
Yu T; Faculty of Chemistry and Chemical Engineering, Yancheng Institute of Technology, No. 1 Xiwangdadao Street, 221051 Yancheng, PR China.
Han Z; Faculty of Chemistry and Chemical Engineering, Yancheng Institute of Technology, No. 1 Xiwangdadao Street, 221051 Yancheng, PR China.
Zhu C; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, No. 5, Zhongguancun South Street, 100081 Beijing, PR China.

Future Med Chem ; 11(23): 2989-3004, 2019 12.

Article em En | MEDLINE | ID: mdl-31659919

Assuntos

Aldeído Redutase/antagonistas & inibidores; Antioxidantes/síntese química; Descoberta de Drogas/métodos; Inibidores Enzimáticos/síntese química; Quinoxalinas/síntese química; Antioxidantes/química; Antioxidantes/farmacologia; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Simulação de Acoplamento Molecular; Estrutura Molecular; Pirazóis/química; Quinoxalinas/química; Quinoxalinas/farmacologia; Relação Estrutura-Atividade

Palavras-chave

1-hydroxypyrazole; aldehyde reductase; aldose reductase; antioxidant activity; diabetic complications; molecular docking; multifunctional inhibitors; oxidative stress; quinoxalinones; structureactivity relationships

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Aldeído Redutase / Inibidores Enzimáticos / Descoberta de Drogas / Antioxidantes Tipo de estudo: Diagnostic_studies Idioma: En Revista: Future Med Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

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