Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.

Kime, Louise; Randall, Christopher P; Banda, Frank I; Coll, Francesc; Wright, John; Richardson, Joseph; Empel, Joanna; Parkhill, Julian; O'Neill, Alex J

Kime, Louise; Randall, Christopher P; Banda, Frank I; Coll, Francesc; Wright, John; Richardson, Joseph; Empel, Joanna; Parkhill, Julian; O'Neill, Alex J.

Afiliação

Kime L; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Randall CP; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Banda FI; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Coll F; Infection Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Wright J; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Richardson J; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Empel J; Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Warsaw, Poland.
Parkhill J; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
O'Neill AJ; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom a.j.oneill@leeds.ac.uk.

mBio ; 10(5)2019 10 29.

Article em En | MEDLINE | ID: mdl-31662453

Assuntos

Farmacorresistência Bacteriana/genética; Inativação Gênica; Mutação; Staphylococcus aureus/genética; Antibacterianos/farmacologia; Farmacorresistência Bacteriana/efeitos dos fármacos; Genótipo; Humanos; Testes de Sensibilidade Microbiana; Fenótipo; Infecções Estafilocócicas/microbiologia; Staphylococcus aureus/efeitos dos fármacos; Sequenciamento Completo do Genoma

Palavras-chave

SARM; Staphylococcus; silenced antibiotic resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Inativação Gênica / Farmacorresistência Bacteriana / Mutação Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: MBio Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos

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