Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity.

Santos, Ana R N; Sheldrake, Helen M; Ibrahim, Ali I M; Danta, Chhanda Charan; Bonanni, Davide; Daga, Martina; Oliaro-Bosso, Simonetta; Boschi, Donatella; Lolli, Marco L; Pors, Klaus

Santos, Ana R N; Sheldrake, Helen M; Ibrahim, Ali I M; Danta, Chhanda Charan; Bonanni, Davide; Daga, Martina; Oliaro-Bosso, Simonetta; Boschi, Donatella; Lolli, Marco L; Pors, Klaus.

Afiliação

Santos ARN; Institute of Cancer Therapeutics , Faculty of Life Sciences , University of Bradford , West Yorkshire , BD7 1DP , UK . Email: k.pors1@bradford.ac.uk.
Sheldrake HM; Institute of Cancer Therapeutics , Faculty of Life Sciences , University of Bradford , West Yorkshire , BD7 1DP , UK . Email: k.pors1@bradford.ac.uk.
Ibrahim AIM; Institute of Cancer Therapeutics , Faculty of Life Sciences , University of Bradford , West Yorkshire , BD7 1DP , UK . Email: k.pors1@bradford.ac.uk.
Danta CC; Institute of Cancer Therapeutics , Faculty of Life Sciences , University of Bradford , West Yorkshire , BD7 1DP , UK . Email: k.pors1@bradford.ac.uk.
Bonanni D; Department of Science and Drug Technology , University of Torino , Via Pietro Giuria 9 , 10125 Torino , Italy.
Daga M; Department of Science and Drug Technology , University of Torino , Via Pietro Giuria 9 , 10125 Torino , Italy.
Oliaro-Bosso S; Department of Science and Drug Technology , University of Torino , Via Pietro Giuria 9 , 10125 Torino , Italy.
Boschi D; Department of Science and Drug Technology , University of Torino , Via Pietro Giuria 9 , 10125 Torino , Italy.
Lolli ML; Department of Science and Drug Technology , University of Torino , Via Pietro Giuria 9 , 10125 Torino , Italy.
Pors K; Institute of Cancer Therapeutics , Faculty of Life Sciences , University of Bradford , West Yorkshire , BD7 1DP , UK . Email: k.pors1@bradford.ac.uk.

Medchemcomm ; 10(8): 1476-1480, 2019 Aug 01.

Article em En | MEDLINE | ID: mdl-31673310

RESUMO

Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Medchemcomm Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google