Copper-Catalyzed Electrophilic Cyclization of N-Propargylamines with Sodium Sulfinate for the Synthesis of 3-Sulfonated Quinolines.

Li, Ling; Zhang, Xing-Guo; Hu, Bo-Lun; Zhang, Xiao-Hong

Li, Ling; Zhang, Xing-Guo; Hu, Bo-Lun; Zhang, Xiao-Hong.

Afiliação

Li L; College of Chemistry and Materials Engineering, Wenzhou University, Chashan Town, Wenzhou, 325035, China.
Zhang XG; College of Chemistry and Materials Engineering, Wenzhou University, Chashan Town, Wenzhou, 325035, China.
Hu BL; College of Chemistry and Materials Engineering, Wenzhou University, Chashan Town, Wenzhou, 325035, China.
Zhang XH; College of Chemistry and Materials Engineering, Wenzhou University, Chashan Town, Wenzhou, 325035, China.

Chem Asian J ; 14(23): 4358-4364, 2019 Dec 02.

Article em En | MEDLINE | ID: mdl-31680431

ABSTRACT

ABSTRACT

A convenient and effective protocol for the synthesis of 3-sulfonated quinolines via copper-catalyzed electrophilic cyclization of N-propargylamines has been developed, in which cheap and stable sodium sulfinates were utilized as green sulfonylation reagents. This cascade transformation involves radical addition, cyclization and dehydrogenative aromatization processes in a one-pot reaction under mild conditions.

Palavras-chave

3-Sulfonated Quinolines; Copper Catalysis; Electrophilic Cyclization; N-Propargylamines; Sodium Sulfinate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Asian J Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY

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