Self-assembled peptide nanoparticles responsive to multiple tumor microenvironment triggers provide highly efficient targeted delivery and release of antitumor drug.

Jiang, Xinglu; Fan, Xiaobo; Xu, Wei; Zhao, Chenggui; Wu, Hailu; Zhang, Rui; Wu, Guoqiu

Jiang, Xinglu; Fan, Xiaobo; Xu, Wei; Zhao, Chenggui; Wu, Hailu; Zhang, Rui; Wu, Guoqiu.

Afiliação

Jiang X; Medical School of Southeast University, Nanjing 210009, People's Republic of China; Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, People's Republic of China.
Fan X; Medical School of Southeast University, Nanjing 210009, People's Republic of China.
Xu W; Medical School of Southeast University, Nanjing 210009, People's Republic of China.
Zhao C; Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, People's Republic of China.
Wu H; Medical School of Southeast University, Nanjing 210009, People's Republic of China; Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, People's Republic of China.
Zhang R; Medical School of Southeast University, Nanjing 210009, People's Republic of China.
Wu G; Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, People's Republic of China. Electronic address: nationball@163.com.

J Control Release ; 316: 196-207, 2019 12 28.

Article em En | MEDLINE | ID: mdl-31682910

Assuntos

Antineoplásicos/administração & dosagem; Doxorrubicina/análogos & derivados; Sistemas de Liberação de Medicamentos; Peptídeos/química; Animais; Antineoplásicos/farmacologia; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Doxorrubicina/administração & dosagem; Doxorrubicina/farmacologia; Liberação Controlada de Fármacos; Feminino; Humanos; Camundongos; Camundongos Nus; Nanopartículas; Neoplasias/tratamento farmacológico; Neoplasias/patologia; Microambiente Tumoral; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Chemotherapy; Peptide; Self-assembly; Triggered drug release; Tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Doxorrubicina / Sistemas de Liberação de Medicamentos / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Holanda

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