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Examination of Cardioprotective Effects of Fabomotizole Hydrochloride in Translational Rat Model of Chronic Heart Failure.
Kryzhanovskii, S A; Tsorin, I B; Stolyaruk, V N; Vititnova, M B; Ionova, E O; Barchukov, V V; Kozhevnikova, L M; Seredenin, S B.
Afiliação
  • Kryzhanovskii SA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. SAK_538@yandex.ru.
  • Tsorin IB; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Stolyaruk VN; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Vititnova MB; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Ionova EO; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Barchukov VV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Kozhevnikova LM; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Seredenin SB; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Bull Exp Biol Med ; 168(1): 33-37, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31741244
ABSTRACT
A translational rat model of chronic heart failure was employed to examine the cardioprotective effect of fabomotizole hydrochloride. Fabomotizole therapy for 28 days (15 mg/kg/day intraperitoneally) restored inotropic function of the left ventricle and increased ejection fraction from 54±3 to 65±3% (p=0.001). The inotropic function returned to normal against the background of significantly reduced myocardial expression of angiotensin (p=0.01) and glucocorticoid (p=0.03) receptors and significant increased expression of sigma-1 receptors (p=0.04). Inhibition of abnormal expression of angiotensin and glucocorticoid receptors responsible for activation of the pathological cascades underlying the postinfarction remodeling of the left ventricle as well as activation of the expression of cytoprotective sigma-1 receptors are viewed as the key features of the cardioprotective action of fabomotizole hydrochloride.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Insuficiência Cardíaca Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Federação Russa

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Insuficiência Cardíaca Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Federação Russa