Impact of the variant allele frequency of ASXL1, DNMT3A, JAK2, TET2, TP53, and NPM1 on the outcomes of patients with newly diagnosed acute myeloid leukemia.

Sasaki, Koji; Kanagal-Shamanna, Rashmi; Montalban-Bravo, Guillermo; Assi, Rita; Jabbour, Elias; Ravandi, Farhad; Kadia, Tapan; Pierce, Sherry; Takahashi, Koichi; Nogueras Gonzalez, Graciela; Patel, Keyur; Soltysiak, Kelly A; Cortes, Jorge; Kantarjian, Hagop M; Garcia-Manero, Guillermo

Sasaki, Koji; Kanagal-Shamanna, Rashmi; Montalban-Bravo, Guillermo; Assi, Rita; Jabbour, Elias; Ravandi, Farhad; Kadia, Tapan; Pierce, Sherry; Takahashi, Koichi; Nogueras Gonzalez, Graciela; Patel, Keyur; Soltysiak, Kelly A; Cortes, Jorge; Kantarjian, Hagop M; Garcia-Manero, Guillermo.

Afiliação

Sasaki K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kanagal-Shamanna R; Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Montalban-Bravo G; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Assi R; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jabbour E; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ravandi F; Division of Hematology-Oncology, Lebanese American University and Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.
Kadia T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Pierce S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Nogueras Gonzalez G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Patel K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Soltysiak KA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cortes J; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kantarjian HM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Cancer ; 126(4): 765-774, 2020 02 15.

Article em En | MEDLINE | ID: mdl-31742675

Assuntos

Biomarcadores Tumorais/genética; Predisposição Genética para Doença/genética; Leucemia Mieloide/genética; Mutação; Doença Aguda; DNA (Citosina-5-)-Metiltransferases/genética; DNA Metiltransferase 3A; Proteínas de Ligação a DNA/genética; Dioxigenases; Feminino; Frequência do Gene; Sequenciamento de Nucleotídeos em Larga Escala/métodos; Humanos; Janus Quinase 2/genética; Estimativa de Kaplan-Meier; Leucemia Mieloide/diagnóstico; Masculino; Pessoa de Meia-Idade; Proteínas Nucleares/genética; Nucleofosmina; Prognóstico; Proteínas Proto-Oncogênicas/genética; Proteínas Repressoras/genética; Estudos Retrospectivos; Proteína Supressora de Tumor p53/genética

Palavras-chave

ASXL1; DNMT3A; JAK2; TET2; TP53; acute myeloid leukemia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Leucemia Mieloide / Predisposição Genética para Doença / Mutação Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

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