Multiplex nucleotide editing by high-fidelity Cas9 variants with improved efficiency in rice.

Xu, Wen; Song, Wei; Yang, Yongxing; Wu, Ying; Lv, Xinxin; Yuan, Shuang; Liu, Ya; Yang, Jinxiao

Xu, Wen; Song, Wei; Yang, Yongxing; Wu, Ying; Lv, Xinxin; Yuan, Shuang; Liu, Ya; Yang, Jinxiao.

Afiliação

Xu W; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China.
Song W; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China.
Yang Y; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China.
Wu Y; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China.
Lv X; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China.
Yuan S; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China.
Liu Y; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China.
Yang J; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture & Forestry Sciences, Shuguang Garden Middle Road No. 9, haidian district, Beijing, China. yangjinxiao@maizedna.org.

BMC Plant Biol ; 19(1): 511, 2019 Nov 21.

Article em En | MEDLINE | ID: mdl-31752697

Assuntos

Proteína 9 Associada à CRISPR/metabolismo; Desoxirribonuclease I/metabolismo; Edição de Genes; Oryza/genética; RNA Guia de Cinetoplastídeos/genética; Proteína 9 Associada à CRISPR/genética; Sistemas CRISPR-Cas; Desoxirribonuclease I/genética; Nucleotídeos/genética; Proteínas de Plantas/genética; Proteínas de Plantas/metabolismo; RNA de Transferência/genética

Palavras-chave

Base editing; CRISPR/Cas9; High-fidelity Cas9 variants; Off-target effect; tRNA-sgRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oryza / RNA Guia de Cinetoplastídeos / Desoxirribonuclease I / Edição de Genes / Proteína 9 Associada à CRISPR Idioma: En Revista: BMC Plant Biol Assunto da revista: BOTANICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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