Establishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells.

Cai, Huanhuan; Li, Bin; Bai, Aobing; Huang, Jie; Zhan, Yongkun; Sun, Ning; Liang, Qianqian; Xu, Chen

Cai, Huanhuan; Li, Bin; Bai, Aobing; Huang, Jie; Zhan, Yongkun; Sun, Ning; Liang, Qianqian; Xu, Chen.

Afiliação

Cai H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China; Department of Cardiologyï¼Zhongnan Hosipital of Wuhan Universityï¼Wuhanï¼430071ï¼China.
Li B; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Bai A; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Huang J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Zhan Y; Children's Hospital, Fudan University, Shanghai, 201102, China.
Sun N; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Liang Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: liangqianqian@fudan.edu.cn.
Xu C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: xu_chen85@fudan.edu.cn.

Exp Cell Res ; 387(1): 111736, 2020 02 01.

Article em En | MEDLINE | ID: mdl-31759053

Assuntos

Cardiomiopatia Hipertrófica/patologia; Células-Tronco Embrionárias Humanas/citologia; Cardiomiopatia Hipertrófica/metabolismo; Linhagem Celular; Células HEK293; Células-Tronco Embrionárias Humanas/metabolismo; Humanos; Hipertrofia/metabolismo; Hipertrofia/patologia; Mutação/genética; Miócitos Cardíacos/citologia; Miócitos Cardíacos/metabolismo; Cadeias Pesadas de Miosina/metabolismo; Fenótipo; Troponina T/metabolismo

Palavras-chave

Cardiac troponin T; Human embryonic stem cells; Hypertrophic cardiomyopathy; R92Q mutation; TALEN

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Hipertrófica / Células-Tronco Embrionárias Humanas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Exp Cell Res Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

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