Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.

Freer, Rosie; Sormanni, Pietro; Ciryam, Prajwal; Rammner, Burkhard; Rizzoli, Silvio O; Dobson, Christopher M; Vendruscolo, Michele

Freer, Rosie; Sormanni, Pietro; Ciryam, Prajwal; Rammner, Burkhard; Rizzoli, Silvio O; Dobson, Christopher M; Vendruscolo, Michele.

Afiliação

Freer R; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Sormanni P; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Ciryam P; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Rammner B; Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA.
Rizzoli SO; Department of Neuro - and Sensory Physiology, University of Göttingen Medical Center, 37073, Göttingen, Germany.
Dobson CM; Department of Neuro - and Sensory Physiology, University of Göttingen Medical Center, 37073, Göttingen, Germany.
Vendruscolo M; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

Heliyon ; 5(11): e02589, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31768427

Palavras-chave

Alzheimer's âdisease; Biophysics; Neurodegenerative diseases; Neuronal vulnerability; Neuroscience; Protein homeostasis; Protein supersaturation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Heliyon Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido

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