Your browser doesn't support javascript.
loading
The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats.
Lv, Wei-Jie; Wu, Xiao-Ling; Chen, Wen-Qian; Li, Yue-Fei; Zhang, Gui-Feng; Chao, Li-Min; Zhou, Jia-Hao; Guo, Ao; Liu, Cui; Guo, Shi-Ning.
Afiliação
  • Lv WJ; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
  • Wu XL; Zhaoqing Medical College, Zhaoqing, Guangdong 526020, China.
  • Chen WQ; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
  • Li YF; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
  • Zhang GF; Zhaoqing Medical College, Zhaoqing, Guangdong 526020, China.
  • Chao LM; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
  • Zhou JH; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
  • Guo A; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
  • Liu C; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
  • Guo SN; Guangdong Research Center for Veterinary Traditional Chinese Medicine and Natural Medicine Engineering Technology, Guangzhou, Guangdong 510642, China.
Oxid Med Cell Longev ; 2019: 7902874, 2019.
Article em En | MEDLINE | ID: mdl-31772709
Generally, depression is the result of complex gene-environment interactions. Recent studies have showed that the gut microbiota can affect brain function through the microbiota-gut-brain axis. However, the underlying mechanism of the microbiota and potential influence of depression remain elusive. We aimed to determine how gut microbiome contributes to the process of depression and further influences the host. Chronic unpredictable mild stress (CUMS) is used to establish a depression model. Fecal microbiota transplant (FMT) is applied to illustrate that depression can be transmitted via microbiota, and metabolism of liver analysis is applied to demonstrate further influence to the liver. We also analyzed the astrocyte activation in the brain by immunofluorescence (IF). Here, we show that the structure of the gut microbiome changes markedly after rats undergo CUMS. Notably, we found that the ratio of Lactobacillus to Clostridium can be a vital index for the development of depression. Depression-like behavior can be duplicated through FMT. Moreover, increased zonulin and fatty acid binding protein-2 indicates that gut barrier integrity is broken after FMT. Subsequently, metabolomics shows that liver metabolic disorder occurs and leads to liver coagulative necrosis. In addition, increased inflammatory cytokine expression and higher astrocyte activation indicate an inflammatory process in the brain. These findings suggest that dysbiosis gut microbiome contributes to development of depression and further causes liver metabolic disorders in a way that may be relevant to the Lactobacillus to Clostridium ratio.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Encéfalo / Depressão / Metabolômica / Inflamação / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Encéfalo / Depressão / Metabolômica / Inflamação / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos