Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRAS<sup>G12C</sup> Inhibition.

Ryan, Meagan B; Fece de la Cruz, Ferran; Phat, Sarah; Myers, David T; Wong, Edmond; Shahzade, Heather A; Hong, Catriona B; Corcoran, Ryan B

Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRAS^G12C Inhibition.

Ryan, Meagan B; Fece de la Cruz, Ferran; Phat, Sarah; Myers, David T; Wong, Edmond; Shahzade, Heather A; Hong, Catriona B; Corcoran, Ryan B.

Afiliação

Ryan MB; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
Fece de la Cruz F; Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Phat S; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
Myers DT; Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Wong E; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
Shahzade HA; Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Hong CB; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
Corcoran RB; Department of Medicine, Harvard Medical School, Boston, Massachusetts.

Clin Cancer Res ; 26(7): 1633-1643, 2020 04 01.

Article em En | MEDLINE | ID: mdl-31776128

Assuntos

Inibidores de Proteínas Quinases; Proteínas Proto-Oncogênicas p21(ras); Retroalimentação; Humanos; Mutação; Oncogenes; Piperazinas; Piridinas; Pirimidinas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

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