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Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARγ expression.
Xiong, Jianwei; Sun, Peng; Wang, Ya; Hua, Xu; Song, Wenyu; Wang, Yan; Wu, Jie; Yu, Wenfeng; Liu, George; Chen, Ling.
Afiliação
  • Xiong J; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
  • Sun P; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
  • Wang Y; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China.
  • Hua X; Department of Physiology, Nanjing Medical University, Longmian Road 101, Nanjing, 211166, China.
  • Song W; Department of Physiology, Nanjing Medical University, Longmian Road 101, Nanjing, 211166, China.
  • Wang Y; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China.
  • Wu J; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China.
  • Yu W; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
  • Liu G; Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, 550004, China. wenfengyu@hotmail.com.
  • Chen L; Institute of Cardiovascular Sciences, Peking University and Key Laboratory of Cardiovascular Sciences, China Administration of Education, Beijing, 100191, China. georgeliu@bjmu.edu.cn.
Diabetologia ; 63(2): 338-350, 2020 02.
Article em En | MEDLINE | ID: mdl-31776610
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidades gama da Proteína de Ligação ao GTP / PPAR gama / Lipodistrofia Generalizada Congênita / Insulina Limite: Animals Idioma: En Revista: Diabetologia Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidades gama da Proteína de Ligação ao GTP / PPAR gama / Lipodistrofia Generalizada Congênita / Insulina Limite: Animals Idioma: En Revista: Diabetologia Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha