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A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.
Kesselring, Lisa; Miskey, Csaba; Zuliani, Cecilia; Querques, Irma; Kapitonov, Vladimir; Laukó, Andrea; Fehér, Anita; Palazzo, Antonio; Diem, Tanja; Lustig, Janna; Sebe, Attila; Wang, Yongming; Dinnyés, András; Izsvák, Zsuzsanna; Barabas, Orsolya; Ivics, Zoltán.
Afiliação
  • Kesselring L; Transposition and Genome Engineering, Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany.
  • Miskey C; Transposition and Genome Engineering, Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany.
  • Zuliani C; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
  • Querques I; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
  • Kapitonov V; Transposition and Genome Engineering, Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany.
  • Laukó A; BioTalentum Ltd, Gödöllo, 2100 Gödöllo, Hungary.
  • Fehér A; BioTalentum Ltd, Gödöllo, 2100 Gödöllo, Hungary.
  • Palazzo A; Department of Biology, University of Bari 'Aldo Moro', Italy.
  • Diem T; Transposition and Genome Engineering, Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany.
  • Lustig J; Transposition and Genome Engineering, Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany.
  • Sebe A; Transposition and Genome Engineering, Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany.
  • Wang Y; Mobile DNA, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Dinnyés A; BioTalentum Ltd, Gödöllo, 2100 Gödöllo, Hungary.
  • Izsvák Z; Mobile DNA, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Barabas O; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
  • Ivics Z; Transposition and Genome Engineering, Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany.
Nucleic Acids Res ; 48(1): 316-331, 2020 01 10.
Article em En | MEDLINE | ID: mdl-31777924
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elementos de DNA Transponíveis / Transposases / Reprogramação Celular / Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elementos de DNA Transponíveis / Transposases / Reprogramação Celular / Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha