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MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Fang, Douglas D; Tang, Qiuqiong; Kong, Yanhui; Wang, Qixin; Gu, Jiaxing; Fang, Xu; Zou, Peng; Rong, Tao; Wang, Jingwen; Yang, Dajun; Zhai, Yifan.
Afiliação
  • Fang DD; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Tang Q; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Kong Y; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Wang Q; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Gu J; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Fang X; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Zou P; Oncology & Immunology Unit, WuXi Apptec (Suzhou) Co, Ltd, 1318 Wuzhong Avenue, Suzhou, Jiangsu Province, China.
  • Rong T; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Wang J; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China.
  • Yang D; Ascentage Pharma (Suzhou) Co, Ltd, 218 Xinghu Street, Suzhou, Jiangsu Province, China. dyang@ascentagepharma.com.
  • Zhai Y; Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. dyang@ascentagepharma.com.
J Immunother Cancer ; 7(1): 327, 2019 11 28.
Article em En | MEDLINE | ID: mdl-31779710
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-mdm2 / Imunomodulação / Microambiente Tumoral / Receptor de Morte Celular Programada 1 / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-mdm2 / Imunomodulação / Microambiente Tumoral / Receptor de Morte Celular Programada 1 / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China